Welcome to FOLD-RATE:
Protein folding rate is a measure of slow/fast folding of proteins
from the unfolded state to native three-dimensional structure. Prediction
of protein folding rates from amino acid sequence is a challenging problem.
Several methods have been proposed for prdicting the folding rates of two- and three state proteins.
We have developed a statistical method based on multiple regression technique for predicting protein folding rates using amino acid composition and properties. Different regression equations have been set up for proteins belonging to different structural classes, all-alpha, all-beta and mixed class proteins. Further, we have derived a general equation applicable for all structural classes of proteins, which may be used for predicting the folding rates for proteins of unknown structural class.
M. Michael Gromiha (2003). Importance of Native-state Topology for Determining the Folding Rate of Two-state Proteins. J. Chem. Inf. Comp. Sci. 43, 1481-1485.
M. Michael Gromiha (2005).
A Statistical Model for Predicting Protein Folding Rates from Amino Acid Sequence with
Structural Class Information. J. Chem. Inf. Model. 45, 494-501 .